Rapamycin-Mimetic Lifestyle

What is Rapamycin-Mimetic Lifestyle?

mTOR (mechanistic target of rapamycin) activity increases with age and drives age-related diseases including cancer, atherosclerosis, diabetes, and immune decline. Rapamycin, the drug, extends lifespan in mice, but long-term human safety is unknown. A rapamycin-mimetic lifestyle uses fasting, exercise, and specific compounds to cyclically suppress mTOR — alternating periods of stress/suppression with recovery for optimal results.

Is there evidence for it?

How do you do Rapamycin-Mimetic Lifestyle?

1. 1.Cycle between mTOR suppression and activation: fast 16-18 hours 3-4 days/week (suppresses mTOR), then eat adequate protein on training days (activates mTOR for muscle building)
2. 2.Perform fasting-mimicking diets (FMD): 5 consecutive days of ~800 cal/day, high-fat low-protein, 1-4 times per year to deeply suppress mTOR
3. 3.Include mTOR-suppressing compounds in diet: green tea (EGCG), curcumin, quercetin (500 mg), and extra virgin olive oil daily
4. 4.Exercise in a fasted state 2-3x/week to amplify AMPK activation and mTOR suppression
5. 5.After fasting or FMD periods, refeed with high-quality protein (30-40g) within 1 hour of breaking fast to rebuild via controlled mTOR activation

How long does it take?

Integrated into daily eating/exercise schedule; FMD periods: 5 days quarterly.

Is it hard to start?

hard.

This is one entry from the library Shift matches against. It is general information, not advice about you, and nothing on this page came from anyone's conversation.