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Methylene Blue Microdosing for Cognition

biohacking · medium · 1 minute daily

What is Methylene Blue Microdosing for Cognition?

Take pharmaceutical-grade methylene blue at 0.5-4mg/kg to enhance mitochondrial electron transport, boost ATP production, and improve memory consolidation and cerebral blood flow. Acts as a non-stimulant nootropic by cycling electrons past blocked mitochondrial complexes.

Is there evidence for it?

EVIDENCEmoderate

How do you do Methylene Blue Microdosing for Cognition?

  1. 1.Get tested for G6PD deficiency BEFORE starting — mandatory blood test to avoid hemolytic anemia
  2. 2.Start with 5mg/day USP-grade methylene blue and titrate up to 15-25mg over 2 weeks
  3. 3.Take in the morning with water on an empty stomach — it will turn urine blue-green (normal)
  4. 4.NEVER combine with SSRIs or MAOIs — methylene blue is a potent MAO inhibitor and can cause fatal serotonin syndrome
  5. 5.Cycle 5 days on, 2 days off to avoid tolerance — doses above 4mg/kg reverse benefits (hormesis)

How long does it take?

1 minute daily.

Is it hard to start?

medium.

Source: Francisco Gonzalez-Lima PhD (UT Austin fMRI studies), AgelessRx clinical protocols
nootropic · mitochondria · cognition · memory · atp · neuroprotection
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