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NMN/NR Supplementation (NAD+ Precursors)

Supplementation · easy · 2 min/day (taking supplements)

What is NMN/NR Supplementation (NAD+ Precursors)?

David Sinclair's protocol centers on boosting NAD+ levels, which decline with age. NMN (nicotinamide mononucleotide) is the immediate precursor to NAD+. Sinclair takes 1g NMN daily with yogurt (fat enhances absorption). NAD+ fuels sirtuin enzymes that protect DNA and the epigenome. Human safety trials at up to 1200 mg/day show NMN is well-tolerated.

Is there evidence for it?

EVIDENCEmoderate — animal studies show significant lifespan extension; human safety trials positive but long-term longevity data in humans still accumulating; NAD+ decline with aging is well-established

How do you do NMN/NR Supplementation (NAD+ Precursors)?

  1. 1.Take 500-1000 mg NMN daily in the morning with a fat-containing food (yogurt, avocado) to enhance bioavailability
  2. 2.Add 500 mg TMG (trimethylglycine) daily as a precautionary methyl donor to prevent potential methyl group depletion from NMN
  3. 3.Store NMN in a cool, dry place (or refrigerate) to maintain stability — it degrades with heat and moisture
  4. 4.If NMN is unavailable or too expensive, NR (nicotinamide riboside) at 300 mg/day is an alternative, though Sinclair considers NMN superior
  5. 5.Get baseline NAD+ levels tested before starting; retest at 3 months to verify supplementation is working

How long does it take?

2 min/day (taking supplements).

Is it hard to start?

easy.

Source: David Sinclair (Harvard); novoslabs.com/best-anti-aging-supplements-that-harvard-scientist-david-sinclair-takes/
supplementation · NAD+ · NMN · NR · david-sinclair · anti-aging · sirtuins
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